Chip designers have considerable experience with these issues, and we should take advantage of this experience. Methodologies that use existing tools, the databases used, the division of labor, and even mundane details like naming conventions, can have a large effect on a project of the scale of the proposed reconstruction. A project with many people working on a common problem, with millions of components, will involve many factors other than just algorithms. Adopt and adapt techniques developed for chip design to neural reconstruction.
#Proofreading software for html tagging manual
Improve the user interface and productivity of manual proofreading, based on engineering experience with graphical systems for integrated circuit design and verification.This disparate data must be reconciled before it can help in reconstruction. Much of this information comes from techniques of genetics and light microscopy, which are very different in terms of the types, scales, and resolution of the data returned.
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Incorporate biological knowledge into the reconstruction process.Replace hard decisions on limited scope with soft decisions and global optimization, based on techniques from communication and coding theory.Several steps are needed to improve the reconstruction of large biological neural systems: This makes it the limiting factor in the size of organism we can reconstruct. The proofreading step involves considerable manual work and represents the bulk of the person-hours expended in reconstruction.
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The reconstruction consists of automated analysis of electron microscopy (EM) photographs, followed by manual proofreading. Biologically, this capability could be used to understand how the nervous system works, in detail to figure out how it develops into its adult form and to compare different animals and genetic variants. The main goal of our lab is to be able to quickly and reliably extract the detailed structure and connections from a volume of neural tissue. Better Reconstruction of Networks of Neurons